Medication Nutrient Depletions
Browse medications and their nutrient depletion profiles. Backed by molecular database analysis.
Data sourced from CTD, ChEMBL, PubMed. How we verify this data →
Sources verified as of April 2026
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ACE Inhibitors Depletions: What Blood Pressure Medications Deplete
ACE inhibitors, like lisinopril, treat hypertension but can deplete zinc. Learn about symptoms, who's affected, and how to manage depletions. 1 medication covered.
What Does Alprazolam Deplete? 4 Nutrients Affected
Alprazolam (Xanax) depletes 4 key nutrients: melatonin, vitamin D, calcium, and magnesium. This is based on molecular database analysis of 13 gene interactions in CTD.
What Does Amphetamine Deplete? 5 Nutrients Affected
Amphetamine depletes 5 key nutrients, including zinc, iron, and magnesium. This profile is based on CTD molecular database analysis of 802 gene interactions.
Anticonvulsants Depletions: What Seizure Medications Deplete
Anticonvulsants (seizure medications) deplete 6 key nutrients, including folate and vitamin D. This class affects ~40 million Americans annually. Learn more.
Anticonvulsants in Psychiatry Depletions: What Mood Stabilizer Medications Deplete
Anticonvulsants like topiramate, gabapentin, and pregabalin, used as mood stabilizers, can deplete 2 key nutrients. Learn about managing these depletions across 3 drugs.
Antipsychotics Depletions: What Antipsychotic Medications Deplete
Antipsychotics treat psychosis but deplete 4 key nutrients: CoQ10, vitamin D, B vitamins, and metabolic factors. This class includes 14 common medications.
What Does Aripiprazole Deplete? 4 Nutrients Affected
Aripiprazole, known as Abilify, may deplete 4 key nutrients, including CoQ10 and Vitamin D. Understand the mechanisms and monitoring markers, based on molecular database analysis.
What Does Atenolol Deplete? 2 Nutrients Affected
Atenolol, a beta-blocker, depletes 2 key nutrients: CoQ10 and melatonin, based on molecular database analysis. Learn about symptoms, monitoring, and food sources.
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ACE Inhibitors Depletions: What Blood Pressure Medications Deplete
ACE inhibitors, like lisinopril, treat hypertension but can deplete zinc. Learn about symptoms, who's affected, and how to manage depletions. 1 medication covered.
What Does Alprazolam Deplete? 4 Nutrients Affected
Alprazolam (Xanax) depletes 4 key nutrients: melatonin, vitamin D, calcium, and magnesium. This is based on molecular database analysis of 13 gene interactions in CTD.
What Does Amphetamine Deplete? 5 Nutrients Affected
Amphetamine depletes 5 key nutrients, including zinc, iron, and magnesium. This profile is based on CTD molecular database analysis of 802 gene interactions.
Anticonvulsants Depletions: What Seizure Medications Deplete
Anticonvulsants (seizure medications) deplete 6 key nutrients, including folate and vitamin D. This class affects ~40 million Americans annually. Learn more.
Anticonvulsants in Psychiatry Depletions: What Mood Stabilizer Medications Deplete
Anticonvulsants like topiramate, gabapentin, and pregabalin, used as mood stabilizers, can deplete 2 key nutrients. Learn about managing these depletions across 3 drugs.
Antipsychotics Depletions: What Antipsychotic Medications Deplete
Antipsychotics treat psychosis but deplete 4 key nutrients: CoQ10, vitamin D, B vitamins, and metabolic factors. This class includes 14 common medications.
What Does Aripiprazole Deplete? 4 Nutrients Affected
Aripiprazole, known as Abilify, may deplete 4 key nutrients, including CoQ10 and Vitamin D. Understand the mechanisms and monitoring markers, based on molecular database analysis.
What Does Atenolol Deplete? 2 Nutrients Affected
Atenolol, a beta-blocker, depletes 2 key nutrients: CoQ10 and melatonin, based on molecular database analysis. Learn about symptoms, monitoring, and food sources.
What Does Atorvastatin Deplete? 3 Nutrients Affected
Atorvastatin (Lipitor) can deplete 3 key nutrients, including CoQ10, vitamin D, and vitamin K2. This is based on molecular database analysis of its mechanism.
Benzodiazepines Depletions: What Anxiety Medications Deplete
Benzodiazepines treat anxiety but deplete 4 key nutrients. Includes alprazolam, clonazepam, diazepam. Over 65 million US prescriptions annually. Learn more.
Beta Blockers Depletions: What Heart Rate Medications Deplete
Beta blockers slow heart rate and lower blood pressure, commonly prescribed for hypertension and anxiety. They deplete CoQ10 and melatonin. Covers 3 drugs.
What Does Bumetanide Deplete? 6 Nutrients Affected
Bumetanide, a loop diuretic, is known to deplete 6 key nutrients, including potassium and magnesium, according to molecular database analysis.
Carbamazepine Depletions: What Seizure/Mood Medications Deplete
Carbamazepine and related medications can deplete 5 key nutrients, including vitamin D and folate. Learn which drugs are included and how to manage depletions.
What Does Chlorthalidone Deplete? 5 Nutrients Affected
Chlorthalidone, a thiazide diuretic, depletes 5 key nutrients including potassium and magnesium, based on molecular database analysis.
What Does Ciprofloxacin Deplete? 0 Nutrients Affected
Ciprofloxacin, a fluoroquinolone antibiotic, does not directly deplete any nutrients, based on molecular database analysis. It is prescribed for UTIs and respiratory infections.
What Does Clonazepam Deplete? 4 Nutrients Affected
Clonazepam (Klonopin) depletes 4 key nutrients including melatonin and vitamin D, based on molecular database analysis. Learn how to monitor and restore these depletions.
Corticosteroids Depletions: What Anti-Inflammatory Medications Deplete
Corticosteroids like prednisone deplete 7 key nutrients by disrupting absorption and increasing excretion. Learn which anti-inflammatory drugs cause depletions.
What Does Dexamethasone Deplete? 7 Nutrients Affected
Dexamethasone, a corticosteroid, depletes 7 key nutrients including calcium and vitamin D, based on molecular database analysis. Monitor nutrient levels to mitigate deficiencies.
What Does Duloxetine Deplete? 4 Nutrients Affected
Duloxetine (Cymbalta) depletes 4 key nutrients: sodium, B vitamins, magnesium, and melatonin. This is based on molecular database analysis of its dual reuptake inhibition.
What Does Enalapril Deplete? 1 Nutrients Affected
Enalapril, prescribed for hypertension and heart failure, depletes 1 nutrient: primarily zinc. This is based on molecular database analysis of 84 gene interactions in CTD.
What Does Escitalopram Deplete? 3 Nutrients Affected
Escitalopram (Lexapro) may deplete 3 key nutrients, including folate, sodium, and melatonin, based on molecular database analysis of its mechanism and clinical effects.
What Does Esomeprazole Deplete? 6 Nutrients Affected
Esomeprazole (Nexium) depletes 6 key nutrients, including vitamin B12, magnesium, and calcium, based on molecular database analysis of its mechanism.
What Does Ethinyl Estradiol Deplete? 7 Nutrients Affected
Ethinyl estradiol, found in many oral contraceptives, depletes 7 key nutrients, including B vitamins, magnesium, and zinc, based on molecular database analysis.
Fluoroquinolone Antibiotics Depletions: What Antibiotic Medications Deplete
Fluoroquinolone antibiotics like ciprofloxacin deplete 5 key nutrients. Learn about magnesium, calcium, iron, zinc, and probiotics affected by these medications.
What Does Fluoxetine Deplete? 3 Nutrients Affected
Fluoxetine, known as Prozac, can deplete 3 key nutrients including folate and sodium, based on molecular database analysis of its mechanisms.
What Does Furosemide Deplete? 6 Nutrients Affected
Furosemide (Lasix) depletes 6 key nutrients, including potassium and magnesium, based on molecular database analysis. Learn how to manage these depletions.
What Does Hydrochlorothiazide Deplete? 5 Nutrients Affected
Hydrochlorothiazide (HCTZ) can deplete 5 key nutrients, including potassium and magnesium. Awareness of these depletions, based on molecular database analysis, is crucial for patient management.
What Does Ibuprofen Deplete? 3 Nutrients Affected
Ibuprofen, a common NSAID, depletes 3 key nutrients: folate, iron, and vitamin C, based on molecular database analysis. Learn more about symptoms and monitoring.
Lamotrigine Depletions: What Seizure/Mood Medications Deplete
Lamotrigine, used for seizures and mood, can modestly deplete folate. Learn about this and how to manage potential depletions. One medication covered.
What Does Lansoprazole Deplete? 6 Nutrients Affected
Lansoprazole, a proton pump inhibitor, can deplete 6 key nutrients including magnesium, B12, and calcium, based on molecular database analysis. Learn more about managing these depletions.
What Does Levofloxacin Deplete? 0 Nutrients Affected
Levofloxacin, a fluoroquinolone antibiotic, does not directly deplete any nutrients, based on molecular database analysis. It is prescribed ~6 million times per year in the US.
What Does Levonorgestrel Deplete? 7 Nutrients Affected
Levonorgestrel, found in oral contraceptives and IUDs, depletes 7 key nutrients including B vitamins, magnesium, and zinc, based on molecular database analysis.
What Does Lisinopril Deplete? 1 Nutrients Affected
Lisinopril, a common ACE inhibitor, depletes 1 key nutrient according to molecular database analysis. Learn about zinc depletion, symptoms, and monitoring strategies.
Lithium Depletions: What Mood Stabilizer Medications Deplete
Lithium, a mood stabilizer, can deplete iodine, calcium, magnesium, and inositol. This class includes 2 drugs commonly prescribed for bipolar disorder. Learn more.
Loop Diuretics Depletions: What Diuretic Medications Deplete
Loop diuretics deplete 6 key nutrients, including magnesium and potassium. Affecting millions, these common medications require careful monitoring.
What Does Lorazepam Deplete? 4 Nutrients Affected
Lorazepam depletes 4 key nutrients: melatonin, vitamin D, calcium, and magnesium, based on molecular database analysis of GABA-A receptor modulation and CYP enzyme induction.
Monoamine Oxidase Inhibitors (MAOIs) Depletions: What Antidepressant Medications Deplete
MAOIs treat depression but can deplete key nutrients. Covers 4 MAOI drugs and their B6 depletion risks. Learn about side effects and management strategies.
Metformin Depletions: What Diabetes Medications Deplete
Metformin, a common diabetes drug, depletes 3 key nutrients, including Vitamin B12. Learn how this impacts nearly 90 million patients annually in the US.
What Does Methylphenidate Deplete? 5 Nutrients Affected
Methylphenidate, commonly known as Ritalin or Concerta, affects 5 key nutrients. This profile, based on molecular database analysis, details depletions, mechanisms, and solutions.
What Does Metoprolol Deplete? 2 Nutrients Affected
Metoprolol, a beta-blocker, is associated with 2 key nutrient depletions based on molecular database analysis. Learn more about CoQ10 and melatonin impacts.
What Does Naproxen Deplete? 3 Nutrients Affected
Naproxen, a common NSAID, is known to deplete 3 key nutrients: folate, iron, and vitamin C, based on molecular database analysis. Learn more about these depletions.
NSAIDs (Nonsteroidal Anti-Inflammatory Drugs) Depletions: What Pain Relief Medications Deplete
NSAIDs like ibuprofen and naproxen deplete iron, folate, and vitamin C. Learn how these common pain relievers impact nutrient levels. Includes 4 drugs.
What Does Olanzapine Deplete? 4 Nutrients Affected
Olanzapine, an antipsychotic, depletes 4 key nutrients including CoQ10, Vitamin D, B vitamins, and metabolic nutrients, based on molecular database analysis.
What Does Omeprazole Deplete? 6 Nutrients Affected
Omeprazole, used by ~30 million in the US, depletes 6 key nutrients including B12 and magnesium, based on molecular database analysis of drug interactions.
Oral Contraceptives Depletions: What Birth Control Medications Deplete
Oral contraceptives can deplete up to 7 key nutrients, including B vitamins, magnesium, and zinc. Over 12 million women in the US use these medications. Learn more.
What Does Pantoprazole Deplete? 6 Nutrients Affected
Pantoprazole, a PPI, depletes 6 key nutrients including magnesium and B12. Understand the risks and what to monitor, based on molecular database analysis.
What Does Paroxetine Deplete? 3 Nutrients Affected
Paroxetine (Paxil) may deplete 3 key nutrients: sodium, folate, and melatonin. This is based on molecular database analysis of its mechanisms and clinical effects.
What Does Phenytoin Deplete? 6 Nutrients Affected
Phenytoin, an anticonvulsant, depletes 6 key nutrients including folate and vitamin D, based on molecular database analysis. Learn more about managing depletions.
Proton Pump Inhibitors (PPIs) Depletions: What Acid Reflux Medications Deplete
Proton Pump Inhibitors (PPIs) like omeprazole treat acid reflux but can deplete 6 key nutrients. Learn about PPI side effects and how to address depletions. 5 medications covered.
What Does Prednisone Deplete? 7 Nutrients Affected
Prednisone, a corticosteroid prescribed ~25 million times per year in the US, depletes at least 7 key nutrients, based on molecular database analysis.
What Does Quetiapine Deplete? 4 Nutrients Affected
Quetiapine (Seroquel) depletes 4 key nutrients: CoQ10, vitamin D, B vitamins, and metabolic nutrients. Learn about symptoms, monitoring, and repletion strategies, based on molecular database analysis.
What Does Rosuvastatin Deplete? 3 Nutrients Affected
Rosuvastatin depletes 3 key nutrients: CoQ10, vitamin D, and vitamin K2, based on molecular database analysis of shared metabolic pathways. Learn more.
What Does Sertraline Deplete? 3 Nutrients Affected
Sertraline, commonly known as Zoloft, may deplete 3 key nutrients, including folate, melatonin, and sodium, based on molecular database analysis.
What Does Simvastatin Deplete? 3 Nutrients Affected
Simvastatin, prescribed to ~20 million Americans annually, can deplete 3 key nutrients, including CoQ10, vitamin D, and vitamin K2, based on molecular database analysis.
Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs) Depletions: What Antidepressant Medications Deplete
SNRIs like venlafaxine and duloxetine can deplete 4 key nutrients. Learn how these 5 drugs affect sodium, B vitamins, magnesium, and melatonin levels.
Selective Serotonin Reuptake Inhibitors (SSRIs) Depletions: What Antidepressant Medications Deplete
SSRIs, including sertraline and fluoxetine, can deplete 3 key nutrients. Learn how these antidepressants affect folate, sodium, and melatonin levels. 5 SSRI drugs covered.
Statins (HMG-CoA Reductase Inhibitors) Depletions: What Cholesterol Medications Deplete
Statins (HMG-CoA Reductase Inhibitors) deplete 3 key nutrients, including CoQ10, vitamin D, and vitamin K2. This class includes 5 common medications.
CNS Stimulants (ADHD Medications) Depletions: What ADHD Medications Deplete
CNS stimulants, like Adderall and Ritalin, deplete 5 key nutrients. Learn how these ADHD medications impact zinc, iron, magnesium, B vitamins, and appetite.
Thiazide Diuretics Depletions: What Blood Pressure Medications Deplete
Thiazide diuretics like hydrochlorothiazide deplete 5 key nutrients. Learn about side effects, who's at risk, and how to manage depletions from these common medications.
Valproate (Valproic Acid / Divalproex) Depletions: What Mood Stabilizer Medications Deplete
Valproate medications, including valproic acid and divalproex, deplete 5 key nutrients. Affecting millions, these drugs impact carnitine, folate, zinc, selenium, and vitamin B12.
What Does Valproic Acid Deplete? 6 Nutrients Affected
Valproic acid, prescribed ~15 million times annually in the US, depletes 6 key nutrients, including carnitine and folate, based on molecular database analysis.
What Does Venlafaxine Deplete? 4 Nutrients Affected
Venlafaxine (Effexor) depletes 4 key nutrients: sodium, B vitamins, magnesium, and melatonin. This is based on molecular database analysis of its dual reuptake inhibition.
This information is generated from peer-reviewed molecular databases including the Comparative Toxicogenomics Database (CTD), ChEMBL, and indexed PubMed research. It is not medical advice. Always consult your healthcare provider before making changes to your medications or supplements. See our methodology →