Prescription Spiral Guides
Understand how one medication leads to another through nutrient depletion.
Data sourced from CTD, ChEMBL, PubMed. How we verify this data →
Sources verified as of April 2026
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The Oral Contraceptive Spiral: How Oral Contraceptives → SSRIs
Oral contraceptives deplete B6, folate, magnesium, leading to depression. SSRIs are often prescribed, further depleting nutrients, worsening the cycle.
The Iron Deficiency Spiral: How Stimulants
Iron deficiency impairs dopamine, mimicking ADHD. Stimulants boost dopamine but worsen iron levels, creating a prescription spiral. Children with picky eating are at risk.
The Low Stomach Acid (Hypochlorhydria) Spiral: How Proton Pump
The low stomach acid spiral: PPIs prescribed for reflux worsen nutrient malabsorption, leading to autoimmune risk. Common in adults 40+ and long-term PPI users.
The PPI Spiral: How Proton Pump → Donepezil
PPIs deplete B12, causing cognitive decline misdiagnosed as dementia. Donepezil doesn't help. Elderly, long-term PPI users at highest risk. Check MMA!
The Statin Spiral: How Statins → Beta-blockers
Statins deplete CoQ10, causing muscle pain, often leading to beta-blockers which worsen CoQ10. Elderly, high-dose users, and those on beta-blockers are most at risk.
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The Oral Contraceptive Spiral: How Oral Contraceptives → SSRIs
Oral contraceptives deplete B6, folate, magnesium, leading to depression. SSRIs are often prescribed, further depleting nutrients, worsening the cycle.
The Iron Deficiency Spiral: How Stimulants
Iron deficiency impairs dopamine, mimicking ADHD. Stimulants boost dopamine but worsen iron levels, creating a prescription spiral. Children with picky eating are at risk.
The Low Stomach Acid (Hypochlorhydria) Spiral: How Proton Pump
The low stomach acid spiral: PPIs prescribed for reflux worsen nutrient malabsorption, leading to autoimmune risk. Common in adults 40+ and long-term PPI users.
The PPI Spiral: How Proton Pump → Donepezil
PPIs deplete B12, causing cognitive decline misdiagnosed as dementia. Donepezil doesn't help. Elderly, long-term PPI users at highest risk. Check MMA!
The Statin Spiral: How Statins → Beta-blockers
Statins deplete CoQ10, causing muscle pain, often leading to beta-blockers which worsen CoQ10. Elderly, high-dose users, and those on beta-blockers are most at risk.
This information is generated from peer-reviewed molecular databases including the Comparative Toxicogenomics Database (CTD), ChEMBL, and indexed PubMed research. It is not medical advice. Always consult your healthcare provider before making changes to your medications or supplements. See our methodology →